GlutaredoxinV1, Main, Exploration, bibRecord, 000D76

Thiol redox control via thioredoxin and glutaredoxin systems.

Identifieur interne : 000D76 ( Main/Exploration ); précédent : 000D75; suivant : 000D77

Thiol redox control via thioredoxin and glutaredoxin systems.

Auteurs : A. Holmgren [Suède] ; C. Johansson ; C. Berndt ; M E Lönn ; C. Hudemann ; C H Lillig

Source :

Biochemical Society transactions [ 0300-5127 ] ; 2005.

RBID : pubmed:16246122

Descripteurs français

KwdFr :
- Animaux (MeSH), Espèces réactives de l'oxygène (métabolisme), Glutarédoxines (MeSH), Humains (MeSH), Mitochondries (métabolisme), Oxidoreductases (métabolisme), Oxydoréduction (MeSH), Stress oxydatif (MeSH), Thiols (composition chimique), Thiorédoxines (métabolisme), Transduction du signal (physiologie).
MESH :
- composition chimique : Thiols.
- métabolisme : Espèces réactives de l'oxygène, Mitochondries, Oxidoreductases, Thiorédoxines.
- physiologie : Transduction du signal.
- Animaux, Glutarédoxines, Humains, Oxydoréduction, Stress oxydatif.

English descriptors

KwdEn :
- Animals (MeSH), Glutaredoxins (MeSH), Humans (MeSH), Mitochondria (metabolism), Oxidation-Reduction (MeSH), Oxidative Stress (MeSH), Oxidoreductases (metabolism), Reactive Oxygen Species (metabolism), Signal Transduction (physiology), Sulfhydryl Compounds (chemistry), Thioredoxins (metabolism).
MESH :
- chemical , chemistry : Sulfhydryl Compounds.
- chemical , metabolism : Oxidoreductases, Reactive Oxygen Species, Thioredoxins.
- chemical : Glutaredoxins.
- metabolism : Mitochondria.
- physiology : Signal Transduction.
- Animals, Humans, Oxidation-Reduction, Oxidative Stress.

Abstract

The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.

DOI: 10.1042/BST20051375
PubMed: 16246122

Affiliations:

Suède

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000D84
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Le document en format XML

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<author><name sortKey="Holmgren, A" sort="Holmgren, A" uniqKey="Holmgren A" first="A" last="Holmgren">A. Holmgren</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Biophysics, The Medical Nobel Institute for Biochemistry, Karolinska Institutet, SE-17177 Stockholm, Sweden. Arne.Holmgren@mbb.ki.se</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Biochemistry and Biophysics, The Medical Nobel Institute for Biochemistry, Karolinska Institutet, SE-17177 Stockholm</wicri:regionArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Glutaredoxins (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Mitochondria (metabolism)</term>
<term>Oxidation-Reduction (MeSH)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Oxidoreductases (metabolism)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Signal Transduction (physiology)</term>
<term>Sulfhydryl Compounds (chemistry)</term>
<term>Thioredoxins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Glutarédoxines (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Mitochondries (métabolisme)</term>
<term>Oxidoreductases (métabolisme)</term>
<term>Oxydoréduction (MeSH)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Thiols (composition chimique)</term>
<term>Thiorédoxines (métabolisme)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Sulfhydryl Compounds</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oxidoreductases</term>
<term>Reactive Oxygen Species</term>
<term>Thioredoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutaredoxins</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term>
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<term>Oxidoreductases</term>
<term>Thiorédoxines</term>
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<term>Humans</term>
<term>Oxidation-Reduction</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Glutarédoxines</term>
<term>Humains</term>
<term>Oxydoréduction</term>
<term>Stress oxydatif</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.</div>
</front>
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<Month>11</Month>
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<Title>Biochemical Society transactions</Title>
<ISOAbbreviation>Biochem Soc Trans</ISOAbbreviation>
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<ArticleTitle>Thiol redox control via thioredoxin and glutaredoxin systems.</ArticleTitle>
<Pagination><MedlinePgn>1375-7</MedlinePgn>
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<Abstract><AbstractText>The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.</AbstractText>
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	Serveur d'exploration sur la glutarédoxine
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Serveur d'exploration sur la glutarédoxine

Thiol redox control via thioredoxin and glutaredoxin systems.

Thiol redox control via thioredoxin and glutaredoxin systems.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki